The crash scene involving a truck and bus on the N3 near Colenso in KwaZulu-Natal is being cleared up by emergency services.
KwaZulu-Natal Road Traffic Inspectorate Sindi Msimang says altogether 45 people were injured in the crash.
Four of the patients are in a serious condition.
The N3 Toll Concession Company says traffic especially vehicles on the way to Gauteng, is severely affected.
N3TC’s Chief Operating Officer Thania Dhoogra says Recovery is under way and traffic is slowly moving past the scene using the Jo’burg bound fast lane.
“Motorists are advised to expect congestion and delays in the area and are requested to please adhere to all instructions of law enforcement officials. Rainy weather conditions are currently being reported all along the N3 toll route, and this is also contributing to difficult driving conditions.”